Letlow launches Trump-backed Senate bid against Cassidy

By Andrew Howard, Erin Doherty, Meredith Lee Hill | 01/20/2026 01:34 PM EST

While Sen. Bill Cassidy has maintained he will win, President Donald Trump’s endorsement of Letlow is a particular blow.

President Donald Trump stands at the podium with Rep. Julia Letlow (R-La.) as he speaks in the White House during the Congressional Ball on Dec. 11, 2025.

President Donald Trump stands at the podium with Rep. Julia Letlow (R-La.) as he speaks in the White House during the Congressional Ball on Dec. 11, 2025. Alex Brandon/AP

Rep. Julia Letlow announced her primary challenge to Sen. Bill Cassidy on Tuesday, just days after President Donald Trump lent his endorsement in the race.

The entrance of Letlow, a Louisiana Republican who has served in Congress since 2021, is a major blow to Cassidy, who was already fending off another MAGA-aligned challenger in a state Trump carried by 22 points in 2024.

“My parents taught me well. They taught me that when the Lord opens a door, you don’t walk through it — you run. It’s an honor to share with you today that I’m officially announcing my candidacy for the United States Senate,” Letlow said at an annual business event with other state leaders in Baton Rouge, Louisiana, according to two people who attended the event. Cassidy was in the room, according to those people.

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Trump upended the primary in the Republican state over the weekend when he preemptively endorsed Letlow. “Should she decide to enter this Race, Julia Letlow has my Complete and Total Endorsement. RUN, JULIA, RUN!!!” Trump wrote on Truth Social.

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